The healthcare sector is facing major challenges with regards to quality and access to care. The Institute of Medicine and the National Academy of Engineering proposed a medicine-engineering partnership to address these challenges. A ‘union of forces’ of scientists, engineers and health professionals and harnessing the power of data and technology can transform systems. Mayo Clinic’s Kern Center for the Science of Health Care Delivery hosts the Information and Decision Engineering program that translates research and development in data and decision science to transform care delivery. The creation of Clinical Engineering Learning Laboratories (CELLs) as a partnership to embed learners, establish big data and analytics environments, and leverage technology such as radio frequency identification will be highlighted. Join the discussion on best practices and lessons learned.